In offices and classrooms across the Bay Area, sick days are piling up again.
But many people testing negative for COVID-19 and the flu may be dealing with something else: a respiratory virus many Americans have likely never heard of - human metapneumovirus, or HMPV.
The virus isn't new. Scientists first identified it in 2001, and it circulates seasonally in the United States, typically from winter through spring, according to the Centers for Disease Control and Prevention.
This year, surveillance data and wastewater monitoring suggest HMPV is spreading widely in parts of Northern California, including in San Francisco and parts of the Bay Area.
The virus can be hard to spot because its symptoms closely resemble those of other respiratory illnesses.
At UC Davis Health, Dean Blumberg, chief of pediatric infectious diseases, said HMPV often looks similar to RSV.
"This includes upper respiratory symptoms that sometimes progress to pneumonia or bronchiolitis and wheezing," he said.
Here's what to know about the virus.
Human metapneumovirus is a respiratory virus that can cause both upper and lower respiratory illness in people of all ages, according to the CDC. It belongs to the same virus family as respiratory syncytial virus, or RSV.
Wastewater monitoring has detected elevated levels of HMPV in several Northern California communities, including San Francisco, Sacramento, Davis and Vallejo, according to data from WastewaterSCAN, a national wastewater surveillance program.
Wastewater testing can help track the spread of viruses in communities even when individuals are not tested.
HMPV has circulated for decades but is less widely known than flu, COVID-19 or RSV.
Because its symptoms are nearly indistinguishable from other respiratory infections, many cases likely go undiagnosed, according to public health experts.
Increased monitoring of respiratory viruses since the COVID-19 pandemic has also brought greater attention to viruses such as HMPV.
Symptoms commonly include:
In some cases, particularly among vulnerable patients, infection can progress to bronchitis or pneumonia, according to the CDC.
Most infections are mild, but some groups face a higher risk of complications.
According to the CDC, higher-risk groups include:
HMPV spreads in similar ways to other respiratory viruses.
There is currently no vaccine and no specific antiviral treatment for HMPV, according to the CDC.
Treatment generally focuses on relieving symptoms. Most people recover on their own with rest, fluids and supportive care.
Public health experts recommend many of the same precautions used to prevent other respiratory illnesses:
UC Davis Health advises contacting a doctor if symptoms become severe or unusual.
Warning signs may include: