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Reid Waldman, 29, a Connecticut-based dermatologist believes there’s a way to make wart removal less painful. His company Veradermics is testing a microneedle patch – basically a high-tech Band-Aid – in phase 2 clinical trials. Emma West, 29, is harnessing the power of the tissue biopsy to bolster precision medicine with her startup Digital Biology. And Connor Tsuchida, 28, is working to translate his Ph.D. research in Nobel-Prize winning chemist Jennifer Doudna’s lab at UC Berkeley to solve the challenge of how to get the next generation of Crispr-based gene therapies into the human body with Azalea Therapeutics.

They are just three of the rising stars from this year’s Forbes 30 Under 30 Healthcare list, who are using technology and ingenuity to develop solutions to some of healthcare’s biggest challenges, from developing new drugs to building new devices to expanding access to care. And also be sure to check out the Forbes 30 Under 30 Science list, where listers like Gregory Chen, 29, have published research in Nature that showed that a single dose of CAR-T cells in patients can hold certain cancers in remission for over a decade. Iemaan Rana, 28, co-authored a paper unveiling the critical link between glyphosate-based herbicides such as Roundup.

New XPrize Will Award $101 Million To Innovators Who Can Reverse Aging

The new contest aims to spur innovation into longer “healthspans” with treatments that can actually reverse age-related degradation in body, mind and immune systems in otherwise healthy adults aged 65-80.“It’s gonna be ridiculously hard to win,” executive director Jamie Justice admitted. But the payoff could be revolutionary.

Read more here.

Pipeline & Deal Updates

Self-amplifying mRNA: The Japanese Ministry of Health has approved ARCT-154, a Covid-19 vaccine jointly developed by CSL and Arcturus Therapeutics. ARCT-154 is a self-amplifying mRNA vaccine, which actually generates multiple copies of mRNA strands in the body, increasing the amount of antigenic proteins produced compared to a conventional mRNA vaccine. A phase 3 trial of ARCT-154 suggests that this method produced a stronger immune response than comparable mRNA vaccines against Covid.

Generative AI: Amazon Web Services announced its working with biotech company Amgen to use generative AI to discover new medicines, as well as speed up the manufacturing process for existing drugs.

Expansion: The Mayo Clinic announced the health system’s board approved a $5 billion plan over six years to redevelop its flagship Rochester, Minnesota campus.

Ambient AI: Paris-based digital health startup Nabla is partnering with electronic health record company NextGen Healthcare and says its AI medical note-taking software has been available to 5,000 NextGen mobile app users since September.

Desmoid Tumors: The FDA has approved nirogacestat, marketed by SpringWorks Therapeutics as Ogsiveo, as an oral therapy for the treatment of patients with progressing desmoid tumors requiring systemic intervention.

Diagnostic Imaging: Canon is entering into a strategic partnership with the Cleveland Clinic to work on the development of advanced digital imaging tools for improving patient care and disease diagnosis.

What To Know About Rapidly Spreading ‘Pirola’ Covid Variant

Pirola, or BA.2.86, is the third most prevalent Covid strain in the U.S. Both Pfizer-BioNTech and Novavax told Forbes their latest vaccines offer some protection from Pirola, and a September clinical trial from Moderna found its latest shot also provided some protection.

Read more here.

Other Healthcare News

Credit ratings agency Moody’s says the outlook for big health insurers is stable for the rest of 2023 despite challenges including the potential loss of millions of Medicaid enrollees.

UnitedHealth Group is estimating $400 billion in revenue next year, as the diversified healthcare giant continues to grow its health insurance business along with medical services via Optum.

Shares of Dutch electronics and health giant Philips fell after the FDA issued a warning about a safety issue with one of its sleep apnea machines.

U.S. life expectancy rose in 2022 after two years of declines fueled by the Covid-19 pandemic, according to CDC data.

Democratic lawmakers have asked the SEC to probe Elon Musk’s Neuralink over claims related to brain implant safety and testing on monkeys.

The U.K. reported its first case of a new swine flu strain in humans.

Across Forbes

The Day Charlie Munger Was Introduced To The World

Israeli Hostages’ Family Members Are Being Threatened By Suspicious Texts

From Crypto To T-Bills: Inside Meow’s Hard Pivot

What Else We are Reading

Blood cancers may arise from CAR-T cells, but experts think only in very rare cases (STAT)

Backlash to Affirmative Action Hits Pioneering Maternal Health Program for Black Women (KFF Health News)

Proposed changes to rules for policing fraud in U.S.-funded biomedical research draw a mixed response (Science)

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